INTERLEUKIN-6 PRODUCTION BY HUMAN MONOCYTES STIMULATED WITH CRYPTOCOCCUS-NEOFORMANS COMPONENTS

Authors
DELFINO D CIANCI L LUPIS E CELESTE A PETRELLI ML CURRO F CUSUMANO V TETI G
Citation
D. Delfino et al., INTERLEUKIN-6 PRODUCTION BY HUMAN MONOCYTES STIMULATED WITH CRYPTOCOCCUS-NEOFORMANS COMPONENTS, Infection and immunity, 65(6), 1997, pp. 2454-2456
Citations number
20
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
Infection and immunity → ACNP
ISSN journal
00199567
Volume
65
Issue
6
Year of publication
1997
Pages
2454 - 2456
Database
ISI
SICI code
0019-9567(1997)65:6<2454:IPBHMS>2.0.ZU;2-W
Abstract
In order to ascertain if Cryptococcus neoformans components can induce interleukin-6 (IL-6) production, we stimulated human whole blood with purified capsular products. Their potencies in stimulating IL-G relea se were mannoproteins > galactoxylomannan = glucuronoxylomannan > alph a(1-3)glucan. IL-6 production was tumor necrosis factor alpha independ ent and required the presence of monocytes and plasma. Since IL-6 can stimulate replication of the human immunodeficiency virus ire monocyti c cells, these findings may he clinically relevant.