INFECTION OF BALB C MICE WITH THE FILARIAL NEMATODE LITOMOSOIDES SIGMODONTIS - ROLE OF CD4(+) T-CELLS IN CONTROLLING LARVAL DEVELOPMENT/

Authors
ALQAOUD KM TAUBERT A ZAHNER H FLEISCHER B HOERAUF A
Citation
Km. Alqaoud et al., INFECTION OF BALB C MICE WITH THE FILARIAL NEMATODE LITOMOSOIDES SIGMODONTIS - ROLE OF CD4(+) T-CELLS IN CONTROLLING LARVAL DEVELOPMENT/, Infection and immunity, 65(6), 1997, pp. 2457-2461
Citations number
28
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
Infection and immunity → ACNP
ISSN journal
00199567
Volume
65
Issue
6
Year of publication
1997
Pages
2457 - 2461
Database
ISI
SICI code
0019-9567(1997)65:6<2457:IOBCMW>2.0.ZU;2-Z
Abstract
Litomosoides sigmodontis is the only filaria which develops from infec tive larvae into adults in immunocompetent laboratory mice. Depletion of CD4(+) T cells from infected BALB/c mice resulted in worm and micro filarial burdens significantly higher than those of infected controls. Th2 cytokines, eosinophilia, and immunoglobulin E, which were strongl y induced in infected controls, were diminished in CD4-depleted mice.