MODULATION OF NEUTROPHIL SUPEROXIDE RESPONSE AND INTRACELLULAR DIACYLGLYCERIDE LEVELS BY THE BACTERIAL PIGMENT PYOCYANIN

Authors
MULLER M SORRELL TC
Citation
M. Muller et Tc. Sorrell, MODULATION OF NEUTROPHIL SUPEROXIDE RESPONSE AND INTRACELLULAR DIACYLGLYCERIDE LEVELS BY THE BACTERIAL PIGMENT PYOCYANIN, Infection and immunity, 65(6), 1997, pp. 2483-2487
Citations number
32
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
Infection and immunity → ACNP
ISSN journal
00199567
Volume
65
Issue
6
Year of publication
1997
Pages
2483 - 2487
Database
ISI
SICI code
0019-9567(1997)65:6<2483:MONSRA>2.0.ZU;2-R
Abstract
Low concentrations of pyocyanin are reported to enhance superoxide pro duction by human neutrophils exposed to various stimuli, yet the mecha nism remains unknown. Using lucigenin-enhanced chemiluminescence, we e xamined the kinetics of the neutrophil superoxide response in the pres ence of pyocyanin. At all concentrations (12.5 to 200 mu M), pyocyanin decreased the peak superoxide response while prolonging the duration of the response. The prolonged response may be associated with an obse rved increase in intracellular diacylglyceride levels due to pyocyanin exposure.