Citation
Pm. Demin et al., Synthesis of tritium labelled 20-hydroxy-hepoxilin A(3), the major hepoxilin metabolite in human neutrophils, J LABEL C R, 42(8), 1999, pp. 773-779
Citations number
10
Categorie Soggetti
Chemistry & Analysis","Inorganic & Nuclear Chemistry
Journal title
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
ISSN journal
03624803
→ ACNP
Volume
42
Issue
8
Year of publication
1999
Pages
773 - 779
Database
ISI
SICI code
0362-4803(199908)42:8<773:SOTL2A>2.0.ZU;2-Q
Abstract
Methyl (8S)-[20-H-3]-8,20-dihydroxy-11,12-epoxy-5Z,9E,14Z-eicosatrienoate (
(8S)[20-H-3]-20-hydroxy-HxA(3) methyl ester), a radioactive analog of the H
xA(3) metabolite was prepared. The synthesis of the 20-hydroxy analog of Hx
A(3) methyl ester was performed by the reduction of the corresponding 20-al
dehydo-HxA(3) with sodium [H-3]-borohydride. The purified [20-H-3]-20-hydro
xy-HxA(3) methyl ester had a specific activity of 2.5-2.7 Ci/mmol.