Direct tritium labeling of multifunctional compounds using organoiridium catalysis. 2.

Citation
Ayl. Shu et al., Direct tritium labeling of multifunctional compounds using organoiridium catalysis. 2., J LABEL C R, 42(8), 1999, pp. 797-807
Citations number
9
Categorie Soggetti
Chemistry & Analysis","Inorganic & Nuclear Chemistry
Journal title
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
ISSN journal
03624803 → ACNP
Volume
42
Issue
8
Year of publication
1999
Pages
797 - 807
Database
ISI
SICI code
0362-4803(199908)42:8<797:DTLOMC>2.0.ZU;2-Q
Abstract
A variety of complex compounds have been labeled with tritium gas by cataly tic exchange in the presence of catalyst precursors [(cod)Ir(dppe)]BF4 or [ (cod)Ir(py)(PCy3)]BF4. In most cases, predictable regioselectivity and high specific activities are achieved. These results are compared in some cases to the results of labeling related compounds with [(cod)Ir(PPh3)(2)]BF4. P rereduction of the catalyst precursors in situ with hydrogen allows the use of smaller quantities of tritium gas and reduces the amount of radioactive waste. Two or more compounds can be labeled simultaneously as mixtures the n separated in the HPLC purification step to increase compound throughput.