Synthesis of labelled oxylipins: Leukotriene A(4) and 8-epi-prostaglandin F-2 alpha

Authors
Shevchenko, VP Nagaev, IY Myasoedov, NF Guy, A Durand, T Vidal, A Vidal, JP Rossi, JC Bezuglov, VV
Citation
Vp. Shevchenko et al., Synthesis of labelled oxylipins: Leukotriene A(4) and 8-epi-prostaglandin F-2 alpha, J LABEL C R, 42(7), 1999, pp. 663-672
Citations number
12
Categorie Soggetti
Chemistry & Analysis","Inorganic & Nuclear Chemistry
Journal title
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
ISSN journal
03624803 → ACNP
Volume
42
Issue
7
Year of publication
1999
Pages
663 - 672
Database
ISI
SICI code
0362-4803(199907)42:7<663:SOLOLA>2.0.ZU;2-E
Abstract
Tritiated leukotriene A(4) and 8-epi-prostaglandin F-2 alpha methyl esters were prepared from the corresponding acetylenic precursors by selective red uction with tritium gas to provide a probe for the metabolite identificatio n of these oxylipins. Partially deactivated Pd-catalysts were prepared from commercial products and their composition was optimized to achieve the bet ter selectivity. A micro-method for the saponification of labelled oxylipin s methyl esters was used.