Room-temperature palladium-catalyzed amination of aryl bromides and chlorides and extended scope of aromatic C-N bond formation with a commercial ligand
Jf. Hartwig et al., Room-temperature palladium-catalyzed amination of aryl bromides and chlorides and extended scope of aromatic C-N bond formation with a commercial ligand, J ORG CHEM, 64(15), 1999, pp. 5575-5580
The reactions of aryl bromides with amines occurs at room temperature when
using Pd(0) and P(t-Bu)(3) in a 1:1 ratio, and the reactions of aryl chlori
des occur at room temperature or 70 degrees C. The arylation of indoles and
the new arylation of carbamates also occur when using P(t-Bu)(3) as ligand
.