Total synthesis of the cholesterol biosynthesis inhibitor 1233A via a (pi-allyl)tricarbonyliron lactone complex

Authors
Bates, RW Fernandez-Megia, E Ley, SV Ruck-Braun, K Tilbrook, DMG
Citation
Rw. Bates et al., Total synthesis of the cholesterol biosynthesis inhibitor 1233A via a (pi-allyl)tricarbonyliron lactone complex, J CHEM S P1, (14), 1999, pp. 1917-1925
Citations number
37
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
ISSN journal
0300922X → ACNP
Issue
14
Year of publication
1999
Pages
1917 - 1925
Database
ISI
SICI code
0300-922X(19990721):14<1917:TSOTCB>2.0.ZU;2-#
Abstract
The total synthesis of the P-lactone cholesterol synthase inhibitor 1233A ( 1) is described employing the oxidative decomplexation of a (pi-allyl)trica rbonyliron lactone (2) as the key synthetic step.