A. Zinke et al., Chronic-active hepatitis in a blue-fronted Amazon (Amazona aestiva aestiva). Clinical, laboratory and morphological findings (Amazona aestiva aestiva), KLEINTIER P, 44(6), 1999, pp. 447
During a period of 4 months, a comprehensive plasma biochemical analysis wa
s performed in a blue-fronted Amazon (Amazona aestiva aestiva) exhibiting n
onspecific clinical signs (Inappetence, Polyuria, Regurgitation). The activ
ities of aspartate aminotransferase [AST], lactatdehydrogenase [LDH] and gl
utamate dehydrogenase [GLDH] in plasma were not elevated, but very low and
decreasing cholinesterase activities (700-364 U/l) were observed. Subsequen
t measurements of the plasma bile acid concentrations [PBAC] (492 and 568 m
u mol/l respectively) suggested a decreased hepatobiliary functional capaci
ty. In addition, a severe hyperglobulinemia was diagnosed (albumin-to-globu
lin (A/G) ratio 0,3-0,16).
The bird died despite treatment and supportive care, exhibiting signs of he
patic encephalopathy. Histopathological analysis revealed a chronic-active
hepatitis. The etiology of the disease is discussed; exposure to hepatotoxi
ns is probable.