Hairy cell leukemia with translocation (11;20)(q13;q11) and overexpressionof cyclin D1

Authors
Ishida, F Kitano, K Ichikawa, N Ito, T Kohara, Y Taniguchi, T Motokura, T Kiyosawa, K
Citation
F. Ishida et al., Hairy cell leukemia with translocation (11;20)(q13;q11) and overexpressionof cyclin D1, LEUK RES, 23(8), 1999, pp. 763-765
Citations number
10
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
LEUKEMIA RESEARCH
ISSN journal
01452126 → ACNP
Volume
23
Issue
8
Year of publication
1999
Pages
763 - 765
Database
ISI
SICI code
0145-2126(199908)23:8<763:HCLWT(>2.0.ZU;2-S
Abstract
We report on a male Japanese patient with hairy cell leukemia (HCL). A cyto genetic study with lipopolysaccharide stimuli showed a novel translocation (11;20)(q13;q11) in 10% of the analyzed cells. Northern blot analysis and R T-PCR analysis for cyclin D1 revealed the overexpression of cyclin D1, alth ough the southern blot analysis of PRAD1 gene showed no rearrangement. In t his particular case, the t(11;20)(q13: q11) might play some role in the onc ogenesis of HCL and the overexpression of cyclin D1. (C) 1999 Elsevier Scie nce Ltd. All rights reserved.