Bilateral thalamic infarction in a patient with factor V Leiden mutation

In a 50-year-old unresponsive man with ophthalmoplegia, bilateral thalamic infarction was detected on magnetic resonance imaging of the brain, A thoro ugh evaluation, including urinalysis, laboratory studies, computed tomograp hy of the brain, chest radiography, lumbar puncture, magnetic resonance ang iography, cerebral angiography, carotid ultrasonography, and transesophagea l echocardiography, revealed no obvious predisposing factors other than het erozygous factor V Leiden mutation. To our knowledge, this is the first rep orted case of bilateral thalamic infarction associated with factor V Leiden mutation, Physicians should consider the possibility of this mutation in p atients with ischemic stroke if no other source is evident.