Re. Lubow et al., The effects of target and distractor familiarity on visual search in de novo Parkinson's disease patients: Latent inhibition and novel pop-out, NEUROPSYCHL, 13(3), 1999, pp. 415-423
De novo Parkinson's disease (PD) patients identified presence or absence of
a unique shape presented with homogeneous distracters. Response time (RT)
was examined as a function of prior experience with target and/or distracte
r assessing latent inhibition (LI; slower RTs to a target that was formerly
a distracter against a background of distracters that were formerly target
s as compared with a novel target with distracters that were formerly targe
ts) and novel pop-out effects. PD patients were slower than controls in det
ecting test-phase targets compared with preexposure-phase targets. Female P
D patients with right-side motor symptoms had elevated LI compared with fem
ale controls and female PD patients with left-side symptoms. Male PD patien
ts with right-side symptoms did not exhibit LI. Results are discussed in te
rms of the dopamine hypothesis and the reciprocal relationship between PD a
nd schizophrenia.