Synthesis of dimer phosphoramidite synthons for oligodeoxyribonucleotide phosphorothioates using diethyldithiocarbonate disulfide as an efficient sulfurizing reagent

Authors
Eleuteri, A Cheruvallath, ZS Capaldi, DC Cole, DL Ravikumar, VT
Citation
A. Eleuteri et al., Synthesis of dimer phosphoramidite synthons for oligodeoxyribonucleotide phosphorothioates using diethyldithiocarbonate disulfide as an efficient sulfurizing reagent, NUCLEOS NUC, 18(8), 1999, pp. 1803-1807
Citations number
22
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES & NUCLEOTIDES
ISSN journal
07328311 → ACNP
Volume
18
Issue
8
Year of publication
1999
Pages
1803 - 1807
Database
ISI
SICI code
0732-8311(1999)18:8<1803:SODPSF>2.0.ZU;2-M
Abstract
An efficient solution phase synthesis of deoxyribonucleoside phosphorothioa te dimers utilizing phosphoramidite approach is described. Diethyldithiocar bonate disulfide (DDD) was found to be an efficient sulfurizing reagent in the conversion of phosphite triesters to phosphorothioate triesters.