Efficient synthesis of deoxyribonucleoside phosphoramidites by eliminatingthe use of additional activator

Authors
Eleuteri, A Capaldi, DC Cole, DL Ravikumar, VT
Citation
A. Eleuteri et al., Efficient synthesis of deoxyribonucleoside phosphoramidites by eliminatingthe use of additional activator, NUCLEOS NUC, 18(8), 1999, pp. 1879-1882
Citations number
29
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES & NUCLEOTIDES
ISSN journal
07328311 → ACNP
Volume
18
Issue
8
Year of publication
1999
Pages
1879 - 1882
Database
ISI
SICI code
0732-8311(1999)18:8<1879:ESODPB>2.0.ZU;2-0
Abstract
An efficient, safe and cost effective synthesis of deoxyribonucleoside phos phoramidites is described. The amine hydrochloride produced as a by-product during the synthesis of nucleoside phosphorbisamidite is used as an intern al activator in the synthesis of phosphoramidites.