Triarylmethyl substituted 4,5-dicyanoimidazoles as activators for Rp-diastereoselective synthesis of TpN dinucleoside methylphosphonates

Authors
Schell, P Laux, WHG Engels, JW
Citation
P. Schell et al., Triarylmethyl substituted 4,5-dicyanoimidazoles as activators for Rp-diastereoselective synthesis of TpN dinucleoside methylphosphonates, NUCLEOS NUC, 18(6-7), 1999, pp. 1169-1174
Citations number
30
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES & NUCLEOTIDES
ISSN journal
07328311 → ACNP
Volume
18
Issue
6-7
Year of publication
1999
Pages
1169 - 1174
Database
ISI
SICI code
0732-8311(1999)18:6-7<1169:TS4AAF>2.0.ZU;2-D
Abstract
2-Triarylmethyl-4,5-dicyanoimidazoles 1-3 were synthesized and tested as ac tivators in the methylphosphonamidite approach. TpN dinucleoside methylphos phonates generated showed diastereoselectivity of up to 8 / 1 (Rp / Sp). Th e influence of the different triarylmethyl substituents on diastereoselecti vity is shown.