A new H-phosphonate approach using N-unprotected monomers and phosphonium condensing reagents

Authors
Wada, T Sato, Y Honda, F Kawahara, S Mochizuki, A Sekine, M
Citation
T. Wada et al., A new H-phosphonate approach using N-unprotected monomers and phosphonium condensing reagents, NUCLEOS NUC, 18(6-7), 1999, pp. 1225-1226
Citations number
4
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES & NUCLEOTIDES
ISSN journal
07328311 → ACNP
Volume
18
Issue
6-7
Year of publication
1999
Pages
1225 - 1226
Database
ISI
SICI code
0732-8311(1999)18:6-7<1225:ANHAUN>2.0.ZU;2-5
Abstract
Oligodexyribonucleotides were synthesized by using N-unprotected H-phosphon ate monomers and a phosphonium-type of new condensing reagent. In the prese nt H-phosphonate approach, N-sulfonyloxaziridine derivatives were successfu lly employed as new reagents for oxidation of the H-phosphonate linkages in the presence of silylating reagents.