Synthesis and enzymatic stability of acyclic thymidine dimer analogues having a constrained anti-glycosidic conformation

Authors
Hsu, LY Yang, KT
Citation
Ly. Hsu et Kt. Yang, Synthesis and enzymatic stability of acyclic thymidine dimer analogues having a constrained anti-glycosidic conformation, NUCLEOS NUC, 18(6-7), 1999, pp. 1261-1262
Citations number
2
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES & NUCLEOTIDES
ISSN journal
07328311 → ACNP
Volume
18
Issue
6-7
Year of publication
1999
Pages
1261 - 1262
Database
ISI
SICI code
0732-8311(1999)18:6-7<1261:SAESOA>2.0.ZU;2-C
Abstract
Our interest to design a novel class of antisense oligonucleotides has lead us to prepare acyclic thymidine dimer analogues having an unique constrain ed antiglycosidic conformation. These dimer analogues showed remarkable res istance to nuclease degradation, such as Nuclease S1, Bovine Spleen Phospho diesterase, and Snake Venom Phosphodiesterase.