Properties of oligonucleotides with six membered carbohydrate mimics and a1,4-relationship between the base moiety and the hydroxymethyl group

Authors
Herdewijn, P Allart, B De Bouvere, B De Winter, H Hendrix, C Hossain, N Schepers, G Verheggen, I Wroblowski, B Van Aerschot, A
Citation
P. Herdewijn et al., Properties of oligonucleotides with six membered carbohydrate mimics and a1,4-relationship between the base moiety and the hydroxymethyl group, NUCLEOS NUC, 18(6-7), 1999, pp. 1371-1376
Citations number
9
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES & NUCLEOTIDES
ISSN journal
07328311 → ACNP
Volume
18
Issue
6-7
Year of publication
1999
Pages
1371 - 1376
Database
ISI
SICI code
0732-8311(1999)18:6-7<1371:POOWSM>2.0.ZU;2-I
Abstract
The properties of oligonucleotides with a six-membered carbohydrate mimic i n the backbone structure and a 1,4-relationship between the base moiety and the hydroxymethyl group are summarized. The different six-membered rings t hat were studied are: 1,5-anhydro-2,3-dideoxy-D-arabino-hexitol, 1,5-anhydr o-2-deoxy-D-mannitol, 1,5-anhydro-2-deoxy-D-altritol and 3-hydroxy-4-hydrox ymethyl-cyclohexane.