Boranopbosphate nucleic acids - A versatile DNA backbone

Authors
Rait, V Sergueev, D Summers, J He, KZ Huang, FQ Krzyzanowska, B Shaw, BR
Citation
V. Rait et al., Boranopbosphate nucleic acids - A versatile DNA backbone, NUCLEOS NUC, 18(6-7), 1999, pp. 1379-1380
Citations number
13
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES & NUCLEOTIDES
ISSN journal
07328311 → ACNP
Volume
18
Issue
6-7
Year of publication
1999
Pages
1379 - 1380
Database
ISI
SICI code
0732-8311(1999)18:6-7<1379:BNA-AV>2.0.ZU;2-K
Abstract
Important chemical and biochemical properties of boranophosphate DNA and RN A oligonucleotides are reviewed. Stereoregular boranophosphate oligomers ca n be synthesized enzymatically and form stable duplexes with DNA. Fully bor onated, non-stereoregular oligothymidylates, synthesized chemically, form h ybrids with poly(A) that have lower melting points than oligothymidylate:po ly(A), yet they nevertheless can support the RNase H mediated cleavage of R NA.