8-aza-7-deazapurine DNA: Synthesis and duplex stability of oligonucleotides containing 7-substituted bases

Authors
Seela, F Becher, G Zulauf, M
Citation
F. Seela et al., 8-aza-7-deazapurine DNA: Synthesis and duplex stability of oligonucleotides containing 7-substituted bases, NUCLEOS NUC, 18(6-7), 1999, pp. 1399-1400
Citations number
6
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES & NUCLEOTIDES
ISSN journal
07328311 → ACNP
Volume
18
Issue
6-7
Year of publication
1999
Pages
1399 - 1400
Database
ISI
SICI code
0732-8311(1999)18:6-7<1399:8DSADS>2.0.ZU;2-2
Abstract
The 7-substituted 8-aza-7-deazapurine phosphoramidites 1a - 3c as well as t he phosphoramidite 4a were synthesized. In comparison to the parent purine oligonucleotide duplexes, the 7-substituted 8-aza-7-deazapurine residues le ad to a significant duplex stabilization.