4 '-thio-RNA: Synthesis, base pairing properties and interaction with dimerization initiation site of HIV-1

Authors
Dukhan, D De Valette, F Marquet, R Ehresmann, B Ehresmann, C Morvan, F Barascut, JL Imbach, JL
Citation
D. Dukhan et al., 4 '-thio-RNA: Synthesis, base pairing properties and interaction with dimerization initiation site of HIV-1, NUCLEOS NUC, 18(6-7), 1999, pp. 1423-1424
Citations number
2
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES & NUCLEOTIDES
ISSN journal
07328311 → ACNP
Volume
18
Issue
6-7
Year of publication
1999
Pages
1423 - 1424
Database
ISI
SICI code
0732-8311(1999)18:6-7<1423:4'SBPP>2.0.ZU;2-S
Abstract
In the present paper, we describe the synthesis of a modified 9-mer oligonu cleotide, 4'-S-r(UGUGCACCU) containing for the first time 4'-thio-guanosine units. This modified 9-mer was found to inhibit in vitro genomic RNA dimer ization as well as the wild type RNA.