The prooligonucleotide approach: Synthesis of mixed SATE-phosphotriester phosphodiester oligonucleotides

Authors
Bologna, JC Tosquellas, G Morvan, F Rayner, B Imbach, JL
Citation
Jc. Bologna et al., The prooligonucleotide approach: Synthesis of mixed SATE-phosphotriester phosphodiester oligonucleotides, NUCLEOS NUC, 18(6-7), 1999, pp. 1433-1434
Citations number
2
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES & NUCLEOTIDES
ISSN journal
07328311 → ACNP
Volume
18
Issue
6-7
Year of publication
1999
Pages
1433 - 1434
Database
ISI
SICI code
0732-8311(1999)18:6-7<1433:TPASOM>2.0.ZU;2-D
Abstract
Synthesis of mixed SATE phosphotriester-phosphodiester prooligos was done f ollowing two ways. Phosphodiesters were generated by selective beta-elimina tion of cyanoethyl using DBU or were introduced with H-phosphonate chemistr y.