Conversion of unprotected amino-link oligonucleotides into their tetramethylguanidinium derivatives

Authors
Greiner, B Uhlmann, E
Citation
B. Greiner et E. Uhlmann, Conversion of unprotected amino-link oligonucleotides into their tetramethylguanidinium derivatives, NUCLEOS NUC, 18(6-7), 1999, pp. 1457-1458
Citations number
2
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES & NUCLEOTIDES
ISSN journal
07328311 → ACNP
Volume
18
Issue
6-7
Year of publication
1999
Pages
1457 - 1458
Database
ISI
SICI code
0732-8311(1999)18:6-7<1457:COUAOI>2.0.ZU;2-W
Abstract
The preparation of tetramethylguanidinium oligodeoxynucleotide (ODN) deriva tives by reaction of the corresponding aminoalkyl-ODN with the uronium salt s HBTU, TBTU or HATU, respectively, is described. The binding affinity of t he new tetramethylguanidinium ODN derivatives was determined.