Tc-99m-labeling of modified RNA

Authors
Hilger, CS Willis, MC Wolters, M Pieken, WA
Citation
Cs. Hilger et al., Tc-99m-labeling of modified RNA, NUCLEOS NUC, 18(6-7), 1999, pp. 1479-1481
Citations number
3
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES & NUCLEOTIDES
ISSN journal
07328311 → ACNP
Volume
18
Issue
6-7
Year of publication
1999
Pages
1479 - 1481
Database
ISI
SICI code
0732-8311(1999)18:6-7<1479:TOMR>2.0.ZU;2-5
Abstract
The synthesis of Tc-99m-labeled, modified RNA is reported. This new class o f radiopharmaceuticals is of potential interest as target specific imaging agents. The preparation of N3S-RNA was achieved by coupling protected MAG(2 )-units to amino modified ON's. The N3S-RNA was Tc-99m-labeled with 90-95% radiochemical yield and specific activities of 3 7MBq/nmol leading to 1:1 - Tc-99m-N3S-aptamers.