Synthesis and characterization of artificial ribonucleases

Authors
Zhdan, NS Kuznetsova, IL Zenkova, MA Vlassov, AV Silnikov, VN Giege, R Vlassov, VV
Citation
Ns. Zhdan et al., Synthesis and characterization of artificial ribonucleases, NUCLEOS NUC, 18(6-7), 1999, pp. 1491-1492
Citations number
3
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES & NUCLEOTIDES
ISSN journal
07328311 → ACNP
Volume
18
Issue
6-7
Year of publication
1999
Pages
1491 - 1492
Database
ISI
SICI code
0732-8311(1999)18:6-7<1491:SACOAR>2.0.ZU;2-F
Abstract
RNA cleaving molecules were synthesized by conjugating components of ribonu cleases A and T1 catalytic centers (imidazole, aliphatic amino and/or carbo xy residues) to intercalating and cationic structures. The artificial ribon ucleases were shown cleave RNA at Py-Pu sites in single-stranded regions.