Visible light activatable binary system of oligonucleotide conjugates for nucleic acids modification

Authors
Dobrikov, MI Gainutdinov, TI Vlassov, VV
Citation
Mi. Dobrikov et al., Visible light activatable binary system of oligonucleotide conjugates for nucleic acids modification, NUCLEOS NUC, 18(6-7), 1999, pp. 1517-1518
Citations number
2
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES & NUCLEOTIDES
ISSN journal
07328311 → ACNP
Volume
18
Issue
6-7
Year of publication
1999
Pages
1517 - 1518
Database
ISI
SICI code
0732-8311(1999)18:6-7<1517:VLABSO>2.0.ZU;2-S
Abstract
A binary system of oligonucleotides conjugated to perfluoroarylazide and pe rylene for sequence-specific photomodification of nucleic acids has been de veloped. The system can be activated by visible light (450-580 nm), reacts 300000 times faster than azide in the absence of perylene and provides high ly efficient (up to 99%) photomodification of target ssDNA.