Parallel-stranded oligonucleotides with alternating d(A center dot isoG)/d(T center dot C) and d(A center dot G)/d(T center dot m(5)isoC) sequences

Authors
Shchyolkina, AK Borisova, OF Jovin, TM
Citation
Ak. Shchyolkina et al., Parallel-stranded oligonucleotides with alternating d(A center dot isoG)/d(T center dot C) and d(A center dot G)/d(T center dot m(5)isoC) sequences, NUCLEOS NUC, 18(6-7), 1999, pp. 1555-1562
Citations number
9
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES & NUCLEOTIDES
ISSN journal
07328311 → ACNP
Volume
18
Issue
6-7
Year of publication
1999
Pages
1555 - 1562
Database
ISI
SICI code
0732-8311(1999)18:6-7<1555:POWADC>2.0.ZU;2-A
Abstract
Parallel-stranded tps) DNA hairpins with alternating d(A.isoG)/d(T.C) (desi gnated as ps-t1) and d(A.G)/d(T.m(5)isoC) (ps-t2) sequences were studied by means of UV, CD and fluorescence spectroscopy. The thermostability of d(A. G)/d(T.m(5)isoC) sequence was close to that of aps d(G.A)/d(T.C). The stabi lity of the ps d(A.isoG)/d(T.C) sequence was even higher than that of a rel ated anti-parallel-stranded taps) d(G.A)/d(T.C) sequence, being unique for ps DNAs studied so far.