Synthesis of oligonucleotide-intercalator conjugates capable to inhibit HIV-1 DNA integration

Authors
Gottikh, MB Volkov, EM Romanova, EA Oretskaya, TS Shabarova, ZA
Citation
Mb. Gottikh et al., Synthesis of oligonucleotide-intercalator conjugates capable to inhibit HIV-1 DNA integration, NUCLEOS NUC, 18(6-7), 1999, pp. 1645-1646
Citations number
2
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES & NUCLEOTIDES
ISSN journal
07328311 → ACNP
Volume
18
Issue
6-7
Year of publication
1999
Pages
1645 - 1646
Database
ISI
SICI code
0732-8311(1999)18:6-7<1645:SOOCCT>2.0.ZU;2-Z
Abstract
This investigation is devoted to design of short "switch" oligonucleotides mono- or bi-functionnalized with intercalating agents capable to form a sta ble tripler with HIV integrase-cognate sequences and inhibit selectively HI V integration. Methods of intercalator incorporation at 5'- and/or 3'-termi nal positions or one of the pyrimidine heterocyclic bases are developed.