Translation arrest by RNase H incompetent antisense oligonucleotides

Authors
Robbins, I Gee, JE Mitta, G Rayner, B Vichier-Guerre, S Leng, M Van der Laan, A van Boom, J Nelson, JS Lebleu, B
Citation
I. Robbins et al., Translation arrest by RNase H incompetent antisense oligonucleotides, NUCLEOS NUC, 18(6-7), 1999, pp. 1667-1668
Citations number
7
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES & NUCLEOTIDES
ISSN journal
07328311 → ACNP
Volume
18
Issue
6-7
Year of publication
1999
Pages
1667 - 1668
Database
ISI
SICI code
0732-8311(1999)18:6-7<1667:TABRHI>2.0.ZU;2-R
Abstract
Most second-generation ON antisense analogs do not activate RNase H. Altern ative strategies to arrest translation in a reticulocyte cell-free assay pr ogrammed by VSV mRNAs have been explored.