Specifically designed polymeric nanospheres increase cellular uptake of unmodified antisense ODNs

Authors
Tondelli, L Laus, M Ricca, A Citro, G
Citation
L. Tondelli et al., Specifically designed polymeric nanospheres increase cellular uptake of unmodified antisense ODNs, NUCLEOS NUC, 18(6-7), 1999, pp. 1677-1679
Citations number
5
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES & NUCLEOTIDES
ISSN journal
07328311 → ACNP
Volume
18
Issue
6-7
Year of publication
1999
Pages
1677 - 1679
Database
ISI
SICI code
0732-8311(1999)18:6-7<1677:SDPNIC>2.0.ZU;2-V
Abstract
The cellular uptake and the inhibitory effect of c-myb unmodified antisense oligonucleotides reversibly bound to new polymeric nanoparticles in HL-60 cellular system have been found to increase by 50 folds if compared with th e free ODN. An initial single dose (320 nM) of the nanoparticle bound unmod ified antimyb ODN has been able to specifically inhibit HL-60 leukemia cell proliferation for at least 8 days.