Comb-type copolymers for controlled DNA delivery

Various comb-type copolymer containing a polycation as a main chain was des ign to construct delivery systems of DNAs. The comb-type copolymers having cell-specific polysaccharides were proved to be useful to deliver DNA to th e target cells in vivo. Of interest, the copolymers with abundant side chai ns of hydrophilic polymers are capable of stabilizing DNA tripler. Further, injectable nanoparticles for controlled releases of DNAs were fabricated f rom the copolymer and a biodegradable polymer.