Activation of spleen lymphocytes by plasmid DNA.

Authors
Rykova, E Laktionov, P Vlassov, V
Citation
E. Rykova et al., Activation of spleen lymphocytes by plasmid DNA., NUCLEOS NUC, 18(6-7), 1999, pp. 1693-1695
Citations number
3
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES & NUCLEOTIDES
ISSN journal
07328311 → ACNP
Volume
18
Issue
6-7
Year of publication
1999
Pages
1693 - 1695
Database
ISI
SICI code
0732-8311(1999)18:6-7<1693:AOSLBP>2.0.ZU;2-M
Abstract
It was shown that plasmid pUC19 DNA stimulates in vitro proliferation of CB A mouse splenocytes in a dose-dependent manner. Stimulation effect of the p lasmid DNA is additive with Con A or LPS, synergistic with PMA and is inhib ited by nonimmunogenic phosphodiester oligonucleotides and Fab fragments of antimouse Ig antibodies. These data and the data of affinity labelling of ODN-binding proteins indicate that immunoglobulin receptors are involved in DNA-induced lymphocyte activation.