Inhibition of HIV-1 integration by mono- & bi-functionalized triple helix forming oligonucleotides

Authors
Brodin, P Gottikh, M Auclair, C Mouscadet, JF
Citation
P. Brodin et al., Inhibition of HIV-1 integration by mono- & bi-functionalized triple helix forming oligonucleotides, NUCLEOS NUC, 18(6-7), 1999, pp. 1717-1718
Citations number
4
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES & NUCLEOTIDES
ISSN journal
07328311 → ACNP
Volume
18
Issue
6-7
Year of publication
1999
Pages
1717 - 1718
Database
ISI
SICI code
0732-8311(1999)18:6-7<1717:IOHIBM>2.0.ZU;2-P
Abstract
HIV-1 DNA integration is carried out by integrase, a viral protein which bi nds to specific sequences located on both extremities of the HIV-1 DNA LTR. Inhibition of integration was observed with submicromolar concentrations o f mono- or bifunctionalized 11-mer oligonucleotide-intercalators, which wer e designed to form an alternate strand triple helix with the U5 LTR end con taining two adjacent purine tracts on opposite strands 5'-GGAAAATCTCT-3'/3' -CCTTTTAGAGA-5'.