P. Ravichandran et al., STATUS OF CIRCULATING LIPID PROFILE IN HUMAN UTERINE CERVICAL-CARCINOMA BEFORE AND AFTER THERAPY, Journal of clinical biochemistry and nutrition, 21(3), 1996, pp. 219-225
To study the status of circulating lipid components in human uterine c
ervical carcinoma, we collected blood from patients with different sta
ges of uterine cervical carcinoma before and after treatment and also
from a control population. Serum lipid was isolated; and the total lip
id and their components such as total cholesterol, high-density lipopr
otein (HDL), cholesterol, HDL, cholesterol, phospholipids, triglycerid
es, free fatty acids, and lipid-bound sialic acid were determined. Som
e of the lipid components like phospholipids, triglycerides, free fatt
y acids, and lipid-bound sialic acid were found to be increased in adv
anced stages (stages III and IV) of carcinoma, when compared with the
values for control subjects. Some of the altered lipid parameters were
adjusted to near normal levels after radiotherapy and radiotherapy co
mbined with chemotherapy. The increase in some of the lipid components
might have been due to the elevated activities of lipolytic enzymes.