Synthesis of chitosan-sugar hybrid and evaluation of its bioactivity

Authors
Li, XB Morimoto, M Sashiwa, H Saimoto, H Okamoto, Y Minami, S Shigemasa, Y
Citation
Xb. Li et al., Synthesis of chitosan-sugar hybrid and evaluation of its bioactivity, POLYM ADV T, 10(7), 1999, pp. 455-458
Citations number
9
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
POLYMERS FOR ADVANCED TECHNOLOGIES
ISSN journal
10427147 → ACNP
Volume
10
Issue
7
Year of publication
1999
Pages
455 - 458
Database
ISI
SICI code
1042-7147(199907)10:7<455:SOCHAE>2.0.ZU;2-C
Abstract
Various chitosan-sugar hybrids were synthesized. The influence of the hybri ds on the active oxygen generation of canine polymorphonuclear leukocyte (P MN) cells tons investigated by measurement of the chemiluminescence (CL) re sponse. The CL responses depended on the degree of substitution (DS) and wa ter solubility of the hybrids. Water-insoluble hybrids stimulated the PMN c ells directly by phagocytosis and the water-soluble ones would sensitize th e PMN cells by a priming effect. (C) 1999 John Wiley & Sons, Ltd.