Basic construction of the functional system in a protein - I. Functional system of modified trypsin (m-trypsin)

Modified trypsin (m-trysin) (essential amino acids for human in trypsin are neglected by replacing them with G (dummy)) was analysed by DEV model. It was found that the proteolytic functional system of trypsin could be assign ed with m-trypsin and essential amino acids are not necessary in this step. Similar results were obtained with m-RNase and non-polar trypsin. These re sults suggest that the basic plan in the construction of trypsin or RNase c an be made from non-polar or non-essential amino acids. The possible involv ement of water is also discussed. Further discussion on the basic plan clar ified the necessity for large DEV and DD values. Large DEV values for site B can be attained mainly by large n(z) values in formula [1] and are neutra lized by large DD values from site E.