Basic construction of the functional system in a protein - II. Functional system of chymotrypsin

Authors
Kiho, Y Okada, Y Iwai, T
Citation
Y. Kiho et al., Basic construction of the functional system in a protein - II. Functional system of chymotrypsin, P JPN AC B, 75(6), 1999, pp. 150-155
Citations number
6
Categorie Soggetti
Multidisciplinary
Journal title
PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES
ISSN journal
03862208 → ACNP
Volume
75
Issue
6
Year of publication
1999
Pages
150 - 155
Database
ISI
SICI code
0386-2208(199906)75:6<150:BCOTFS>2.0.ZU;2-Y
Abstract
Near to the active sites of trypsin, the DEV model could predict the functi onal sites from which the proteolytic functional system of trypsin was defi ned. In the case of chymotrypsin, however, the assignment of functional sit es failed. When some appropriate portion is removed from chymotrypsin, the functional system could be defined near the active sites. It is inferred th at the proteolytic functional system of chymotrypsin is not independent of other portions of the molecule.