Basic construction of the functional system in a protein - III. Information transfer in a closed circuit

From sites B and E in the DEV model, a closed circuit can be made in which the active sites of trypsin are found. In the presence of a substrate, the hydrophobic amino acid sequence near to the cleavage site of the substrate enters into the trypsin closed circuit. This closed circuit is considered t o be a channel for information transfer. Information transfer can start fro m anywhere in the molecule and enters into the closed circuit. The mode of transfer is unique to biological catalysis, in contrast to chemical catalys is which operates by a one way transfer of information.