The present review provides an overview of the distribution of dopaminergic
fibers and dopaminoceptive elements within the avian telencephalon, the po
ssible interactions of dopamine (DA) with other biochemically identified sy
stems as revealed by immunocytochemistry, and the involvement of DA in beha
vioral processes in birds.
Primary sensory structures are largely devoid of dopaminergic fibers, DA re
ceptors and the D1-related phosphoprotein DARPP-32, while all these dopamin
ergic markers gradually increase in density from the secondary sensory to t
he multimodal association and the limbic and motor output areas. Structures
of the avian basal ganglia are most densely innervated but, in contrast to
mammals, show a higher D2 than D1 receptor density. In most of the remaini
ng telentephalon D1 receptors clearly outnumber D2 receptors. Dopaminergic
fibers in the avian telencephalon often show a peculiar arrangement where f
ibers coil around the somata and proximal dendrites of neurons like baskets
, probably providing them with a massive dopaminergic input. Basket-like in
nervation of DARPP-32-positive neurons seems to be most prominent in the mu
ltimodal association areas.
Taken together, these anatomical findings indicate a specific role of DA in
higher order learning and sensory-motor processes, while primary sensory p
rocesses are less affected. This conclusion is supported by behavioral find
ings which show that in birds, as in mammals, DA is specifically involved i
n sensory-motor integration, attention and arousal, learning and working me
mory. Thus, despite considerable differences in the anatomical organization
of the avian and mammalian forebrain, the organization of the dopaminergic
system and its behavioral functions are very similar in birds and mammals.
(C) 1999 Elsevier Science Ltd. All rights reserved.