Effectiveness of oxybutynin hydrochloride in the treatment of enuresis nocturna - A clinical and urodynamic study

Objective: To find the efficacy and optimal dosage of oxybutynin HCl in a g roup of enuretic children, who were non-responsive to imipramine. Material and Methods: Thirty-six patients with enuresis who were non-responsive to i mipramine were urodynamically assessed and subsequently treated with oxybut ynin hydrochloride (HCl). Patients with inadequate bladder storage function (IBSF) were started on 10-mg daily oxybutynin HCl for one month. If the in itial treatment was found to be inadequate, the dose was increased to 15 mg daily. The dose in patients who were non-responsive to 15-mg daily dose wa s increased to 20-mg daily dose. Patients who were normal urodynamically we re treated with a dose of 15 mg daily for one month. Results: Before the tr eatment, 17 patients had IBSF (47.2%). The majority of the patients (88.2%) with IBSF were responsive to the 15-mg daily oxybutynin HCl. The treatment in patients with normal bladder function was generally unsuccessful. Concl usions: Oxybutynin HCl in sufficient dosages seems to be effective in the t reatment of enuretic patients with IBSF.