One-pot synthesis of pharmacologically active diamines via rhodium-catalysed carbonylative hydroaminomethylation of heterocyclic allylic amines

Authors
Rische, T Muller, KS Eilbracht, P
Citation
T. Rische et al., One-pot synthesis of pharmacologically active diamines via rhodium-catalysed carbonylative hydroaminomethylation of heterocyclic allylic amines, TETRAHEDRON, 55(32), 1999, pp. 9801-9816
Citations number
75
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON
ISSN journal
00404020 → ACNP
Volume
55
Issue
32
Year of publication
1999
Pages
9801 - 9816
Database
ISI
SICI code
0040-4020(19990806)55:32<9801:OSOPAD>2.0.ZU;2-L
Abstract
Pharmacologically active derivatives of phenothiazine, iminodibenzyl, carba zole and pyrazole are prepared with high yields and chemoselectivity by the reaction of the corresponding N-allylic or N-methallylic compounds, primar y or secondary amines, carbon monoxide and hydrogen in the presence of [Rh( cod)Cl](2) as catalyst via a one pot hydroformylation - amine condensation - reduction sequence. (C) 1999 Elsevier Science Ltd. All rights reserved.