Conformational analysis of (R,S)-4-amido-2,4-dimethyl-butyric acid derivatives

Authors
Hoffmann, RW Lazaro, MA Caturla, F Framery, E Valancogne, I Montalbetti, CAGN
Citation
Rw. Hoffmann et al., Conformational analysis of (R,S)-4-amido-2,4-dimethyl-butyric acid derivatives, TETRAHEDR L, 40(33), 1999, pp. 5983-5986
Citations number
29
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
33
Year of publication
1999
Pages
5983 - 5986
Database
ISI
SICI code
0040-4039(19990813)40:33<5983:CAO(AD>2.0.ZU;2-3
Abstract
NMR spectra of various N-acyl derivatives of (R,S)-4-amino-2,4-dimethyl-but yric acid show these compounds to be biconformational, populating the confo rmers 4 and 5 of the molecular backbone. Both predominant conformers have t he amide group gauche to the main chain, (C) 1999 Elsevier Science Ltd. All rights reserved.