Synthesis of azepane scaffolds on solid support for combinatorial chemistry

Authors
Gauzy, L Le Merrer, Y Depezay, JC Clerc, F Mignani, S
Citation
L. Gauzy et al., Synthesis of azepane scaffolds on solid support for combinatorial chemistry, TETRAHEDR L, 40(33), 1999, pp. 6005-6008
Citations number
19
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
33
Year of publication
1999
Pages
6005 - 6008
Database
ISI
SICI code
0040-4039(19990813)40:33<6005:SOASOS>2.0.ZU;2-Q
Abstract
Enantiopure C-2-symmetric azepanes have been synthesized on solid support a s scaffolds for the synthesis of peptidomimetics in combinatorial chemistry . The key step involves Pink resin as a formal equivalent of ammonia in the nucleophilic opening of L-iditol bis-epoxide. (C) 1999 Published by Elsevi er Science Ltd. All rights reserved.