Production of bicyclic and tricyclic triterpenes by mutated squalene-hopene cyclase

Authors
Pale-Grosdemange, C Merkofer, T Rohmer, M Poralla, K
Citation
C. Pale-grosdemange et al., Production of bicyclic and tricyclic triterpenes by mutated squalene-hopene cyclase, TETRAHEDR L, 40(33), 1999, pp. 6009-6012
Citations number
13
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
33
Year of publication
1999
Pages
6009 - 6012
Database
ISI
SICI code
0040-4039(19990813)40:33<6009:POBATT>2.0.ZU;2-X
Abstract
Mutagenesis of Tyr420 to Ala in the catalytic cavity of squalene-hopene cyc lase of Alicyclobacillus acidocaldarius resulted in an altered product spec trum. Besides hopene and diplopterol, this mutant produced significant amou nts of the bicyclic alpha- and gamma-polypodatetraenes and minor amounts of the tricyclic 13 alpha(H)-malabaricatriene. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.