Solid phase synthesis of peptide C-terminal semicarbazones and aldehydes

Authors
Patterson, JA Ramage, R
Citation
Ja. Patterson et R. Ramage, Solid phase synthesis of peptide C-terminal semicarbazones and aldehydes, TETRAHEDR L, 40(33), 1999, pp. 6121-6124
Citations number
24
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
33
Year of publication
1999
Pages
6121 - 6124
Database
ISI
SICI code
0040-4039(19990813)40:33<6121:SPSOPC>2.0.ZU;2-O
Abstract
A new linker based on the dibenzosuberyl system was developed in order to s ynthesise peptide C-terminal semicarbazones which can be readily converted into peptide C-terminal aldehydes. The method uses Fmoc-methodology and pro ceeds with no loss of stereochemical integrity. (C) 1999 Elsevier Science L td. All rights reserved.