An efficient synthesis of (R)-(-)-baclofen

Citation
P. Resende et al., An efficient synthesis of (R)-(-)-baclofen, TETRAHEDR-A, 10(11), 1999, pp. 2113-2118
Citations number
35
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON-ASYMMETRY
ISSN journal
09574166 → ACNP
Volume
10
Issue
11
Year of publication
1999
Pages
2113 - 2118
Database
ISI
SICI code
0957-4166(19990604)10:11<2113:AESO(>2.0.ZU;2-X
Abstract
In this report we describe an efficient synthesis of (R)-(-)-baclofen, a se lective GABA(B) agonist used as an antispastic agent. Our strategy is based on an enantioselective deprotonation of a cyclobutanone easily obtained by [2+2] cycloaddition of 4-chlorostyrene and dichloroketene. (C) 1999 Publis hed by Elsevier Science Ltd. All rights reserved.