Resolution of albuterol acetonide

Authors
Caira, MR Hunter, R Nassimbeni, LR Stevens, AT
Citation
Mr. Caira et al., Resolution of albuterol acetonide, TETRAHEDR-A, 10(11), 1999, pp. 2175-2189
Citations number
37
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON-ASYMMETRY
ISSN journal
09574166 → ACNP
Volume
10
Issue
11
Year of publication
1999
Pages
2175 - 2189
Database
ISI
SICI code
0957-4166(19990604)10:11<2175:ROAA>2.0.ZU;2-X
Abstract
The (R)-enantiomer of albuterol has been isolated via resolution of albuter ol acetonide with (2S,3S)-di-O-benzoyl- or (2S,3S)-di-O-toluoyltartaric aci d. The absolute configuration of the resolved acetonide was assessed by H-1 NMR analysis of its (R)-Mosher's ester, and confirmed by an X-ray crystal structure determination of the (R)-phenylethylurea derivative of the (S)-en antiomer. (C) 1999 Elsevier Science Ltd. All rights reserved.