Stereoselective chemoenzymatic synthesis of both enantiomers of protected 4-amino-2-pentanone

Authors
Besse, P Ciblat, S Canet, JL Troin, Y Veschambre, H
Citation
P. Besse et al., Stereoselective chemoenzymatic synthesis of both enantiomers of protected 4-amino-2-pentanone, TETRAHEDR-A, 10(11), 1999, pp. 2213-2224
Citations number
50
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON-ASYMMETRY
ISSN journal
09574166 → ACNP
Volume
10
Issue
11
Year of publication
1999
Pages
2213 - 2224
Database
ISI
SICI code
0957-4166(19990604)10:11<2213:SCSOBE>2.0.ZU;2-B
Abstract
An acetal protected 4-amino-2-pentanone was synthesised by two different ro utes in 10 and seven steps, respectively, the key step being a microbiologi cal reduction. Both enantiomers of the amine were obtained enantiomerically pure. (C) 1999 Elsevier Science Ltd. All rights reserved.