G. Kehrer et H. Bosseckert, Energy turnover of human large bowel adenocarcinoma in comparison to adenomatous and normal mucosa, THERMOC ACT, 333(1), 1999, pp. 33-37
Malignant tumors differ from healthy tissue, among other things, in their c
ell kinetics and in a changed energy metabolism. Therefore the objective of
this study is to find an answer to the question, whether these cell-biolog
ical differences result in a changed thermal output. For this purpose biops
ies were taken from human colorectal carcinomas (n=10), on the occasion of
colonoscopic examinations; the former were placed into a microcalorimeter,
and the occurring thermal flow rates were measured. The results were then c
ompared with corresponding data of biopsies taken from normal colorectal mu
cosa (n=16) and with data of biopsies taken from colorectal adenomatous tis
sue (n=18), which can be looked upon as a precancerosis. While tissue from
adenocarcinomas showed a significantly higher (t=0/1 h: p<0.005/0.025) ener
gy turnover than normal mucosa, adenomatous tissue did not differ from heal
thy mucosa. Thus an enhanced overall energy turnover with colorectal adenoc
arcinomas cannot be verified until the stage of malignancy has been arrived
at. (C) 1999 Elsevier Science B.V. All rights reserved.