Host resistance to infection - genetic control of lipopolysaccharide responsiveness by TOLL-like receptor genes

Authors
Qureshi, ST Gros, P Malo, D
Citation
St. Qureshi et al., Host resistance to infection - genetic control of lipopolysaccharide responsiveness by TOLL-like receptor genes, TRENDS GEN, 15(8), 1999, pp. 291-294
Citations number
24
Categorie Soggetti
Molecular Biology & Genetics
Journal title
TRENDS IN GENETICS
ISSN journal
01689525 → ACNP
Volume
15
Issue
8
Year of publication
1999
Pages
291 - 294
Database
ISI
SICI code
0168-9525(199908)15:8<291:HRTI-G>2.0.ZU;2-Y
Abstract
Gram-negative bacterial lipopolysaccharide evokes a protective inflammatory response in the normal host. Through genetic analysis of mutant mice, the gene encoding TOLL-like receptor 4 (Tlr4) was recently identified as a crit ical component of this host defense mechanism. Tlr4 is a member of an ancie nt gene family that regulates antimicrobial host defense in plants, inverte brates and mammals.